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How to take Modafinil
Modafinil may be habit-forming. Never share modafinil with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away modafinil is against the law.
Modafinil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
You may take modafinil with or without food.
Modafinil is usually given for 12 weeks or less.
If you are taking modafinil to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to a mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.
Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and modafinil may be necessary to best treat your condition.
Modafinil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor’s instructions about all your other treatments for this disorder.
Call your doctor if you continue to have excessive sleepiness even while taking modafinil.
Taking modafinil does not take the place of getting enough sleep.
Store at room temperature away from moisture and heat.
Keep track of the amount of medicine used from each new bottle. Modafinil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
How does Modafinil work?
Regrettably, decades of study have never been able to reach a definitive response. From the body of medical literature, scientists have managed to discover “puzzle pieces” about how Modafinil functions without having the ability to gather the whole puzzle.
One of Modafinil’s most well-known effects involves inhibiting the reuptake of dopamine, which consequently increases extracellular levels of dopamine within the brain. Modafinil, however, does not directly boost dopamine production, but instead “enables” the dopamine available to be used at any given moment.
Additional Neurotransmitters are also thought to participate in Modafinil’s mechanism of action, such as increased histamine production and decreased GABA generation – many studies on modafinil’s wake-promoting mechanism were concentrated on monoaminergic effects demonstrating modafinil stimulates histamine (HA), norepinephrine (NE), serotonin (5-HT), dopamine (DA), and orexin systems from the brain. But scientists have yet to be able to isolate one site of activity or locate receptor binding.
Modafinil Raises the activity of CYP3A4 enzymes inside the liver, therefore decreasing plasma levels of drugs metabolized by the exact same enzyme.
Additional important features of Modafinil are enclosed below
- The elimination half-life of 12-15 hours
- Reaches peak concentrations in the blood after around 2 hours following ingestion
- 90 percent of Modafinil is Metabolized in the liver to modafinil acid and modafinil sulfone, the two of which can be inactive metabolites
- The body eliminates Modafinil mainly through urine
- Half-life and peak plasma Levels of Modafinil are higher in patients with kidney or liver impairments
There are many neurotransmitters on which Modafinil works. These are as follows:
1. Orexin: neurons that respond to orexin are found in the hypothalamus. It helps in the sleep-wake cycle. There are increased amounts of dopamine and norepinephrine in the hypothalamus with the activation of these neurons, and there is a rise in histamine levels. There are many studies that show that a defect in orexin systems contributes to narcolepsy disease.
2. Dopamine: another mechanism on which Modafinil functions is the increase in the total amount of dopamine. It functions together with the blockage of this dopamine transporter that exists in the mind since these will be the molecules that act to remove dopamine from the synaptonemal complex. Thus, modafinil increases the amount of dopamine and also its accessibility because of its actions to work upon. Modafinil works similar to caffeine as it makes the mind exceptionally focused and increases the levels of dopamine D2 receptors.
3. Histamine: this is a chemical that works as a neurotransmitter. It has an important part in the regulation of the sleep-wake cycle. Neurons of Histamine are observed in the hypothalamus in the brain. Besides this, these are present in tuberomammillary nuclei that are also a part of the hypothalamus. It elevates the amount of histamine.
4. Norepinephrine Similar to adrenaline, Norepinephrine boosts vigilance and alertness. Another effect of Norepinephrine is that it accelerates the heartbeat.
5. Serotonin: the neurotransmitter serves a vital role in the regulation of mood and general well-being. Studies reveal that Modafinil is efficient in enhancing the brain’s serotonin production and regulation.
6. Suppression of Gamma-aminobutyric acid that leads to rising in histamine. GABA promotes sleep and induces relaxation. Therefore, it also accounts for the vigilance effects of Modafinil.
7. Glutamate is a key excitatory neurotransmitter. An excitatory transmitter enhances the production of an electrical signal in receiving neurons. In other words, it’s involved in the cognitive function (attention and memory) of the brain. Modafinil leads to increased glutamate levels.